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Taking advantage of the benefits presented by induced protein degradation, Hulme et al

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The compound of 2 is (a) phenyl unsubstituted or substituted with 1, 2, or 3 R 7 , (b) 5- or 6-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N and S, wherein the heteroaryl is unsubstituted or substituted with 1 or 2 halogen, C 1-3 alkyl, or cyclopropyl, (c) C 1-6 alkyl unsubstituted or mono-substituted, disubstituted, or trisubstituted with halogen, OH, CF 3 , CN, deuterium, or (C 3-6 )cycloalkyl, (d) (C 3-6 )cycloalkyl unsubstituted or optionally mono-substituted, disubstituted or trisubstituted with halogen, C 1-6 alkyl, OC 1-3 haloalkyl, OH, CF 3 , or CN, (e) (C 3-6 )alkylC(O)NH 2 , (f) 4- to 6-membered heterocyclyl containing 1 or 2 heteroatoms independently selected from N, O and S wherein the heterocyclyl is unsubstituted or substituted with 1 or 2 substituents selected from CH 3 or oxo, (g) CH 2 -heteroaryl unsubstituted or substituted with 1 or 2 methyl substituents, (h) CH 2 -aryl, (i) CH 2 -heterocyclyl, (j) C(O) (C 1-6 )alkyl, (k) C(O) (C 3-6 )cycloalkyl, (l) C(O) (C 1-6 )heterocyclyl, (m) C(O) aryl, (n) SO 2 (C 1-6 )alkyl, (o) SO 2 (C 3-6 )cycloalkyl, or 8