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Hypoxia-inducible factor-1 induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

It has been suggested that, when using rodent models of ASD, approximately 1520 animals per genotype, treatment, and sex are required to ensure adequate power and reliability of behavioral outcomes [102]

However, several studies also showed a narrow therapeutic window, with excessive ozone concentrations leading to cytotoxicity and endothelial dysfunction, particularly in culture systems with compromised redox buffering

however, this traditional notion is challenged by recent studies showing that the gutliver axis rather liver alone plays an important role in systemic acetaldehyde clearance