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465 The anterior cingulate cortex, essential for emotional pain processing, shows increased blood flow in patients with PDPN, a hyperperfusion state that normalizes following duloxetine treatment

Massage and muscle spasm research confirms that manual therapy reduces muscle tone, improves local circulation, and decreases pain

While DAMPs signal cellular stress or damage through receptors such as TLR4, cGASSTING, and NLRs, PAMPs mimic microbial infection and trigger proinflammatory responses via PRRs, particularly TLRs 165 and C-type lectin receptors (CLRs)

The argument: the hype and the evidence are telling two different stories Heres what the mouse data actually shows, and it is worth reading carefully because it is genuinely the whole case