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3, BSO induced more significant downregulation of antiapoptotic proteins in GBC-SD cells than in RBE cells, which may explain the fact that BSO in combination with cisplatin increased cell apoptosis to a greater extent in GBC-SD cells than in RBE cells

Second, the loss of hormonal signaling results in an altered balance between the activity of osteoblasts and osteoclasts 336,337

Serum thyroxine concentrations are elevated in more than 90% of hyperthyroid cats, making this a very sensitive test of thyroxine-induced hypermetabolism.22, 23 False-positive test results are rare to nonexistent, suggesting that hyperthyroxinemia is a specific test for feline hyperthyroidism