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Certain spore-forming gut bacteria stimulate intestinal serotonin production, which can alter signaling in the brain and has been linked to changes in mood and gastrointestinal motility [45]

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Although NOD as a risk factor for PDAC has been known for years, the evaluation of NOD in the general population as a clinically actionable PDAC risk group has not realized its potential due to the complex, individually distinct nature of PDAC, diabetes, and NOD