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Due to the unexpected lack of pharmacological activity exhibited by Lys-MDMA, the initial statistical analysis plan could not be implemented

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In accurate DSS-induced and chronic IL-10 deficient colitis models, the pharmacological blockade or genetic ablation of 5-HT 7 resulted in an increased severity of colitis, whereas receptor stimulation showed an anti-inflammatory effect [161], although another study contradictorily reported that the inhibition of 5-HT 7 receptor signaling ameliorated both DSS- and TNBS-induced colitis [162]