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This could lead to the prediction of future escape variants and the design of vaccine antigens that encode structural epitopes that are more difficult to escape

Leveraging the Broad Institutes Cancer Dependency Map (DepMap), in addition to our own in vitro and in vivo CRISPR-Cas9 screens, we show that dietary deprivation of riboflavin, or genetic and chemical targeting of its processing pathways, results in collapse of oxidative phosphorylation due to the structural disassembly of mitochondrial complex I and II