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It is also possible that generation of nicotinamide by CD38 may regulate SIRTUINs activity, since nicotinamide is an endogenous inhibitor of the SIRTUINs [62-63]

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These diverse biological activities have made GHK-Cu a focal point of research and development in dermatology, cosmetic formulation, and regenerative medicine, where its potential for anti-aging applications and holistic tissue health enhancement is actively explored