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Pulmonary Fibroblast Models Pathological fibrosis, an endpoint of many chronic inflammatory diseases, involves the excessive deposition of ECM by activated fibroblasts

We then built the isobologram of the corresponding dose-response curves with a fixed dose ratio of R and compared the expected mixture of the two doses that produced an effect equal to half of the maximal effect produced by the individual drugs and to the experimental value (see later in methods)

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Similarly, STEAPs can reduce copper 51 , facilitating its transport across the endosomal membrane in ATP7B-deficient cells (see scheme in Fig