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fALS and sALS can affect any voluntary muscle but their presentation, phenotype and progression are variable (Wei et al., 2019), hindering differential diagnosis (Swinnen and Robberecht, 2014

The exogenous addition of substrates for CSE (Cys), MPST (3MP) or SQR (H 2 S) lowered endogenous radical load, in line with the notion that enzymatically generated S 0 species contribute to radical scavenging (Fig

coli DNA glycosylases that were initially observed coordinate a [4Fe-4S] cluster that mediates their DNA binding and substrate recognition ( Conclusion and future perspectives With the current understanding that several [4Fe-4S] cluster enzymes interact with the late-acting CIA complex and play a critical role in DNA metabolism, there is a window of opportunity to accelerate our understanding of how Fe-S biogenesis can regulate metabolic processes (e.g., maintain genomic integrity)