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doi:10.1080/03602532.2017.1293682 Substrate-level phosphorylation is defined as the production of ATP or GTP following the transfer of a phosphate group from a substrate to ADP or GDP

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HO-1 is also known to be regulated by hypoxia-inducible factor 1 and anti-inflammatory signaling cascades mediated by AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPKs), and phosphatidylinositol 3-kinase (PI3K)

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Kenney: Clearly, the researchers themselves are not saying that TMAO is the real cause of atherosclerosis

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