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Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

10.1038/nrn1035 60 DeMaagdG.PhilipA

Its leaf extracts contain a variety of pharmacologically active constituents, such as flavonoid glycosides (approximately 24%) and terpenoid lactones (6%, including ginkgolides A, B, C, and J, as well as bilobalide), which exhibit multi-target therapeutic properties ( Macrophages constitute the predominant cellular population within atherosclerotic plaques and constitute a major contributor to AS etiology ( in vitro RAW264.7 macrophage model co-stimulated with LPS and ATP to recapitulate the inflammatory injury phenotype of macrophages in atherosclerotic disease