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Treatment with isocitrate, alpha-ketoglutarate, or succinate at optimal concentrations increased lifespan, whereas supplementation of D-malate at a concentration of 110 mM decreased lifespan (Edwards et al., 2015)

This is critical because injured tendons, ligaments, and damaged gut mucosa have poor blood supply

For unknown reasons, the melanocyte stem cell system fails earlier than other adult stem cell populations, which leads to hair graying in most humans and mice, according to the NYU study

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