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Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

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Fatty Acids When anionic lipids (Figure 87) are formulated into LNPs, they can interact with cationic lipids to form ion pairs, which can improve the pH-sensitivity of the LNPs and promote endosomal membrane destabilization, thus increasing nucleic acids delivery efficiency