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Gupta T, Singh J, Kaur S, Sandhu S, Singh G, Kaur IP

& Sherman, J

Microenvironmental effects need to be systematically evaluated: previous studies have shown that ACE induces apoptosis by inhibiting HIF-1, 51 , so whether hypoxia regulates ACE sensitivity through HIF-1 signaling deserves further investigation

EdU assays showed a significant enhancement in cell proliferation in the AngII+C75 group ( Supplementary Figure S5A, B ), while flow cytometry revealed a lower apoptotic rate in the AngII+C75 group compared to the AngII group ( Supplementary Figure S5C, D )