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Her advice to future interns is simple

Hence, this issue has not been properly solved

Additional work is also required to assess the prevalence and impact of dual use, whether the use of newer tobacco products is more likely to lead to complete abstinence from combustible tobacco use, and whether these products and e-cigarettes have adverse health effects if they are continued long-term

In these models, active smoking in human subjects is reproduced by exposing animals to cigarette smoke collected at the filter end of the cigarette (mainstream smoke), whereas passive smoking is mimicked by exposing animals to environmental smoke from the lit end of a smoldering cigarette (sidestream component)