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Based on a 5-km time improvement of 2.5% or about 30 seconds (SD = 1 minute) with Protandim , and no improvement in the placebo group, about 34 runners in total were needed (Effect size for ANOVA = f = 0.25, which is moderate, statistical power = 80%, two-sided alpha error probability = 5%, two measurements per group, two groups, correlation amongst repeated measures = 0.50, F-test Family, ANOVA repeated measures, within-between interaction, G*Power 3.1.2, Universitt Kiel, Germany)

Behavioral modification Lifestyle changes like quitting smoking, reducing stress, improving diet, etc

Sikiric et al

But they happen frequently because patients make assumptions that do not survive contact with their actual vial