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HIF-1 accumulation in response to TLR4 activation by LPS has been demonstrated in a range of cell types (Ramanathan et al., 2009

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10.1016/S1474-4422(18)30490-3 Lancet Neurol

Resveratrol, a polyphenolic stilbene, displays concentration-dependent biphasic actions, at low doses it can weakly mimic estrogenic effects via ER activation, whereas at higher pharmacologic concentrations it acts as an ER antagonist, inhibits aromatase transcription, and disrupts co-activator recruitment to the ER complex, thereby exerting anti-proliferative and pro-apoptotic effects in ER-positive breast cancer cells (192)