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In IDD tissues, FTH1 expression is reduced, thereby disrupting iron homeostasis and increasing ferroptosis

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in the cell and help in the maintenance of cellular redox balance

There are two types of glutamate receptors: ionotropic glutamate receptors (iGluRs), which are ligand-gated ion channels, and metabotropic glutamate receptors (mGluRs), which are G protein-coupled receptors (Pin and Duvoisin, 1995