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[13] In the setting of acute isoniazid overdose or toxicity, extraordinarily high doses of pyridoxine are used as an antidote: the recommended approach is to administer pyridoxine in a total amount equal to the amount of isoniazid ingested

doi: 10.1007/s00125-014-3490-7

Therefore, consistent with the burden estimates for this measure under OMB control number 0938-1270, we estimate the removal of this measure will decrease burden for voluntary reporting for the CY 2025 reporting period by 383 hours (4,590 ASCs 50 percent of ASCs 0.167 hours per ASC) at a savings of $21,088 (383 hours $55.06/hour) and 765 hours annually (0.167 hours 4,590 ASCs) at a savings of $42,121 (765 hours $55.06/hour) for mandatory reporting beginning with the CY 2026 reporting period