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The specific localization along with intense expression of these enzymes in renal carcinoma has led to the design of kidney-selective prodrugs that bypass earlier steps of the mercapturic acid pathway (GST, GT, and peptidase): these compounds include S -(guanin-6-yl)-L-cysteine (Elfarra et al., 1995), S -(6-Purinyl)-L-cysteine (Hwang and Elfarra, 1991

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Artificial intelligence to deep learning: machine intelligence approach for drug discovery