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SKU: 19262994182
Price: 25.48 USD
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Description

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells

Markedly elevated concentrations of total homocysteine (tHcy) in blood are the biochemical hallmark of cobalamin-related remethylation disorders

These defects were accompanied by disrupted phosphorylation of the IRS, as well as down-regulated expression of mitochondrial proteins PPAR co-activator 1 (PGC1) and uncoupling protein-2 (UCP-2) [200]