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Cancers 13 (6), 1434

(2022) 13:e00524

By diminishing the DNA binding capacity of hypoxia response elements in Caco-2 and IEC-6 cells, contradictory findings suggest that butyrate suppresses the transcriptional activity of HIF-dependent hypoxia-sensitive genes 79

In contrast to the synthesis, that occurs only intracellularly, the degradation or catabolic part of the GSH cycle, takes place partially extracellularly and partially inside cells