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Patients may experience mild to severe infusion reactions such as chills, itching, high temperature, hives, difficulty breathing, and chest pain

Specifically, oxidative stress is associated with PC development, progression and the response to therapy

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Mutations in KEAP1 are classified as loss-of-function mutations and are distributed throughout the entire KEAP1 genome, with particular enrichment observed within the Kelch domain, which interacts with the DLG and ETGE motifs of NRF2 9,35,80