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this finding held in a multivariate analysis controlling for other mortality risk factors (hazard ratio 1.97 [95% CI 1.18-3.30]) [18]

Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells

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Conclusion: Subcutaneous weekly REP 2139-Mg in combination with TDF and low-dose pegIFN appears safe and effective against HBV/HDV infection in patients with compensated cirrhosis and CSPH, although the use of pegIFN warrants close clinical/laboratory monitoring