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However, as with other lipid-based nanosystems, key challenges remain, including ensuring long-term formulation stability, evaluating safety with repeated topical application, and scaling up production for clinical-grade batches [123, 124, 134]

SCH-C also improved intestinal permeability dysfunction across three IBD model systems by enhancing epithelial barrier integrity through upregulation of ZO-1 and occluding [479]