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Furthermore, the model can be extended, in particular by using multi-omics approaches, such as metabolomics of the bacterial consortium and transcriptomics of the respective immune cells, providing mechanistic insights into the chemical-microbiome-immune interaction triangle

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(3) Imaging parameters: Pfirrmann classification: Lumbar disc degeneration was graded on sagittal T2-weighted MR images using the Pfirrmann classification system 15

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