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Since COX-2 is expressed in many cell types, including platelets and microglia, it is involved in many physiological processes

Therefore, targeted regulation of mitochondrial quality control, timely enhancing mitophagy in the early stage of the disease or effectively curbing its over-activation in the late stage, is a promising but challenging treatment strategy

doi: 10.1002/ijc.30630 184

Treatment with dexamethasone was found to significantly reduce TLR4 and MyD88 expression in monocytes derived from patients with tuberculous meningitis (TBM) (169)