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Alternative formulations, such as iron protein succinylate, may be more tolerable than ferrous salts, but are untested in RLS patients as of May 2026 (Pantopoulos 2024)

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These include: Endocrine (hormone) disorders, such as Cushing's disease and hypothyroidism (low thyroid hormones) Lipedema, a buildup of fat, most often in the legs, but sometimes in the arms as well Other rare fatty tissue disorders, such as Madelung's disease and familial multiple lipomatosis Your doctor might also order an imaging test, such as an MRI or ultrasound, to look at the fatty lumps inside your body and see if they look typical for Dercum's disease