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Conflicts of interest Kong D is an Editorial Board member of the Journal Cancer Drug Resistance , while the other authors have declared that they have no conflicts of interest

This implies that upstream modulators like KEAP1 may be more important than direct Nrf2 modulation as the primary mechanism 104

After incubation for 15 min at 30 C, 1,000 rpm using a 3 mm shaking diameter, cell debris was removed by centrifugation (4,400 g at 4 C for 30 min) and the supernatants were analysed by HPLCMS at two different dilutions (undiluted and four times diluted with 67% methanol, 0.2% hydrochloric acid in H 2 O)

This route could be experimentally measured by the assessment of TEER