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Propolis potentiates methotrexate anticancer mechanism and reduces its toxic effects

E., Myrhed, M

The first step is likely catalyzed by glutamatecysteine ligase (Gcs1), which catalyzes the condensation of Cys and glutamate to form -glutamylcysteine, which is then converted to GSH by the addition of Gly to the C-terminal of -glutamylcysteine by glutathione synthase (Gsh2) ( the source of 4-phosphopantetheine for essential post-translational activation of non-ribosomal peptide synthetases and polyketide synthases in fungi (Stack et al., 2009

What this means for you: low circulating levels may indicate the kind of chronic oxidative stress that promotes early cancer development