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The oil-in-water method is suitable for water-soluble drugs, involving the dissolution of drugs and organic materials in the oil phase, followed by conversion to an aqueous phase through emulsification or ultrasound, resulting in the formation of nanoparticles with good dispersibility and stability 119

Gallbladder-related events, a risk with rapid weight loss across all obesity medications, occurred in a small percentage of participants and were associated with very rapid early weight loss without adequate dietary fat intake

combining them increases the risk of liver damage and may also increase the risk of muscle side effects

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