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Besides the scavenging function of NO, the plant cell can overcome elevated ROS levels by activating the antioxidant system

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As discussed in gut health research more broadly, microbiome disruption drives: Intestinal permeability Systemic inflammation Impaired neurotransmitter production Immune dysregulation In the context of long COVID, gut dysfunction may represent both a consequence of the initial infection and an ongoing driver of systemic inflammatory and neurological symptoms

DAMPs can not only bind to pattern recognition receptors (PRR) to subsequently promote adaptive immunity by inducing DC activation, but can also enhance adaptive immune responses by affecting the presentation of antigens associated with dying cells, promoting phagocytic action ( eat-me signaling, e.g., calreticulin), and facilitating antigen extraction and processing ( present-me signaling, e.g., F-actin or HMGB1) (111, 115, 117)