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The patient inclusion criteria were as follows: no prior treatment with anthracyclines or iSGLT2, aged between 30 and 70 years, and a glomerular filtration rate (GFR) greater than 30 ml/min/1.73 m 2

In case of oxidative stress, the imbalance of oxidation and antioxidant imbalance caused by various external or internal stimuli (Sies, 2015), plays a pivotal role in toxicities