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Muc1 promotes migration and lung metastasis of melanoma cells

10.1007/s12031-013-0031-7 214 WangY

This enzyme, along with other gastric contents, can damage the mucous membranes and epithelial barrier it contacts, digesting intercellular connections (Reference Kowalik and Krzeski28)

The inhibition of MM growth was additionally seen when co-culturing the cancer cells with human HS-5 stromal cells using a transwell model, further showing the compounds potent effect even in conditions mimicking the bone marrow microenvironment (Rogers et al., 2020)