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Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

Discussion Using a vitamin B 12 deficiency phenotype definition, consistent with previous reports [1, 2], there were 487 (6.8%) deficient individuals of White European ancestry receiving metformin in the UKB cohort out of a total of 7173

The loss of these types of cells results in a significant decrease in the function of cholinergic synapses followed by the reduced release of Ach in the brain, which, based on the cholinergic deficit hypothesis, is the logic behind cognitive dysfunction and behavioral disabilities in AD patients and those with advanced age (M Tata et al., 2014)

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