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This dietary model has been indicated as the Western diet (WD) and is associated with overnutrition and an increased risk of obesity and related comorbidities [183, 184]

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In addition, HIV-1 Tat inhibits autophagy and proteasomal degradation in microglia and astrocytes, which in turn modulates EV biogenesis pathways and may amplify intercellular propagation of inflammatory signals [58, 59]