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Moreover, the efficacy of these drugs in MC4R KO mice aligns with clinical studies, indicating that MC4R KO mice serve as a reliable animal model for obesity research

Importantly, dietary manipulations induce systemic responses that are not limited to the tumor itself and influence other stromal behaviors, such as the immune system and overall homeostasis

Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Roth JA, Swisher SG , Walsh GL, Vaporciyan AA, Mehran RJ, Antonoff MB

Behaviorally, these compounds showed similar benefits in motor function, cognition, and emotional regulation, with potential applications in neurodegenerative diseases, anxiety, and pain management