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These are usually non-fatal overdoses

Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events

They had symptoms of encephalomyopathy, lactic acidosis and myocardial hypertrophy, which were consistent with the characteristics of mitochondrial injury myopathy caused by FBXL4 gene mutation