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doi: 10.3389/fimmu.2018.01070 Received 03 March 2018 Accepted 30 April 2018 Published 24 May 2018 Volume 9 - 2018 Edited by Pinyi Lu, Biotherapeutics, Inc., United States Reviewed by Jianlin Geng, University of Alabama at Birmingham, United States

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A major cellular function of PRC2 in development is to catalyze the methylation of histone H3 lysine 27 (H3K27), promote the formation of repressed chromatin domains marked by trimethylated H3K27 (H3K27me3), and thereby impose epigenetic thresholds for the activation of lineage-specific genes 2