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The enhancing effect of theobromine on the levels of acetylcholine-related enzymes, dopamine, and especially noradrenalin confirms its beneficial role on the cognitive reserve and, consequently, a possible reducing effect on the cognitive decline underlying aging and Alzheimers disease [216]

Other medicines like Atropine, Amitriptyline (used in psychiatric illness), Phenobarbital, Carbamazepine (used to treat fits), Probenecid (used to treat gout)and Itraconazole (antifungal) should be used with caution