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When disrupted, whether by harsh cleansing, pollution, antibiotic use or stress, this microbial homeostasis collapses, leading to barrier fragility, redness and micro-inflammation, a biochemical precursor to accelerated ageing

Female adolescents of reproductive age must use reliable contraception, and a urine pregnancy test should be obtained at baseline and at each follow-up visit

Contains sweetener (3 mg sodium saccharin and 25.6 mg sodium cyclamate) per 5g sachet

Lumens were fixed by adding prewarmed 4% paraformaldehyde (PFA, AAJ19943K2, Thermo Scientific) to the side ports and incubating at 37C for 30 minutes