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Using canonical correlation (CCA) methodology to assess associations between sets of variables, it was shown that increased fibrinogen was correlated with both objective as well as subjective cognitive deficits at 6 and 12 post COVID (70)

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Hence, future studies are required to explore the therapeutic potential of caffeine and adenosine receptor antagonists in both nave and dependent rats, at different stages of the disease

However, in recent years, concerns have been raised about their safety, such as local irritation at the vaccination site and potential neurotoxicity