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Advise males with female partners of reproductive potential to use effective contraception during treatment with Pemetrexed Injection and for 3 months after the last dose [see Warnings and Precautions (5.7) and Use in Specific Populations (8.3)]

Axitinib reduced the destruction of tight junction proteins and reduced BBB permeability in mice, while increasing spatial awareness, exploration, associative memory, working memory, and lowering -amyloid levels (Yuan, et al