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Acknowledgements The authors are thankful to the Nursing team and supporting staff at the Bangalore Medical College and Research Institute and to the volunteers for their participation in the study

Consistent with all of our previous findings, the arthritis control group revealed a significant increase in serum levels of IL-1, TNF-, and IL-17 and a significant reduction in the levels of IL-4 in arthritic rats

NAMPT and NRK1/2 are also localized to the nucleus and cytosol 48,83,84 , suggesting that only the final step of salvage is performed in the mitochondria, with a mitochondrial NMN transporter, Slc25a45, recently proposed 85