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This is due to orange oils hydroxylated polymethoxyflavones (a group of flavonoid compounds mainly found in citrus plants) that are associated with modulating key signaling proteins related to cell proliferation and apoptosis

It has occurred in at least nine separate cancer bioassays and one fourteen-day study in B6C3F1 mice

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Growth of cancerous cells, metabolite synthesis, tissue disturbances, and involvement of normal cells in the disease interfere with normal biological functioning and cause pain, organ failure, and cancer-related symptoms 59