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Without efficient escape, released PROTACs may remain trapped within endosomal/lysosomal compartments, thereby limiting their access to cytosolic or nuclear targets and E3 ligases and ultimately attenuating degradation efficacy

5 The use of the revised Mayo Score obviates the need for biopsy in risk stratification

Reduced autophagic activity not only leads to the delayed and abnormal accumulation of denatured proteins and dysfunctional organelles but also, through various pathways, results in endothelial dysfunction and intimal thickening, exacerbating vascular aging

for example, in a high-cholesterol and high-fructose diet model, polysaccharides like those from dried tangerine peel showed hepatoprotection through antioxidative and anti-inflammatory actions (Wang et al., 2024)