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Both play a core role in 1C metabolism, affecting a wide range of physiological activities such as protein and nucleic acid synthesis, methylation of DNA, and post-translational modification of proteins ( As the first large-scale investigation into the association of serum folate and vitamin B12 levels with all-cause mortality in patients with MASLD, the main strengths of the current study are that it has a follow-up time of more than 20 years, adjusts for a variety of potential confounders, and takes into account the complex sampling design to enable the included samples to be more representative and to facilitate the generalization of the current findings

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Phase 2 clinical trials involved 338 adults with obesity (BMI 30 or more) and overweight (BMI of 2729.99) with one or more weight-related conditions such as high blood pressure, high cholesterol levels, heart disease, and type 2 diabetes