glutathione reductase and nadph glutathione disulfide (GSH) redox cycle in hydroperoxide metabolism. GSSG, Glutathione Disulfide Glutathione reductase catalytic cycle |

J Inherit Metab Dis 36(1):6373 Cordero MD, De Miguel M, Moreno Fernndez AM, Carmona Lpez IM, Garrido Maraver J, Cotn D et al (2010) Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease

DJ: Funding acquisition, Writing review & editing

So here we have something similar to a classical depletion-repletion study used to identify the function of essential vitamins and minerals, only the deficiency is caused by a defective gene instead of a highly purified deficient diet

Therefore, the aim of this review is to summarize the current information about the potential efficacy of ACNs in the treatment of RA, and to analyze and discuss their mechanisms of action and findings