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In order to reverse this trend, PRP Treatment has been increasingly utilized

19 The 2024 Wilderness Medical Society (WMS) Practice Guidelines updated the definition of HACE as severe AMS with neurological signs

Synapses are particularly vulnerable to ferroptotic stress due to their high metabolic demand, lipid-rich membranes, and dependence on tightly regulated redox homeostasis (Lish et al., 2025)